KMID : 1044520220850040341
|
|
Tuberculosis and Respiratory Diseases 2022 Volume.85 No. 4 p.341 ~ p.348
|
|
Transbronchial Lung Cryobiopsy for Diagnosing Interstitial Lung Disease: A Retrospective Single-Center Experience
|
|
Park Jin-Han
Jang Ji-Hoon Kim Hyun-Kuk Jang Hang-Jea Lee Sung-Gun Kim Seong-Ho Kim Ji-Yeon Choi Hee-Eun Han Ji-Yeon Kim Da-Som Kang Min-Kyun Kang Eun-Su Kim Il-Hwan Lee Jae-Ha
|
|
Abstract
|
|
|
Background: An accurate diagnosis in patients with interstitial lung diseases (ILDs) by multidisciplinary discussion (MDD) based on histopathologic information is essential for optimal treatment. Transbronchial lung cryobiopsy (TBLC) has increasingly been used as a diagnostic alternative to surgical lung biopsy. This study aimed to evaluate the appropriate methods of TBLC in patients with ILD in Korea.
Methods: A total of 27 patients who underwent TBLC were included. TBLC procedure details and clinical MDD diagnosis using TBLC histopathologic information were retrospectively analyzed.
Results: All procedures were performed under general anesthesia with the fluoroscopic guidance in the operation room using flexible bronchoscopy and endobronchial balloon blocker. The median procedure duration was less than 30 minutes, and the median number of biopsies per participant was 2. Most of the bleeding after TBLC was not severe, and the rate of pneumothorax was 25.9%. The most common histopathologic pattern was alternative (48.2%), followed by indeterminate (33.3%) and usual interstitial pneumonia (UIP)/probable UIP (18.5%). In the MDD after TBLC, the most common diagnosis was idiopathic pulmonary fibrosis (33.3%), followed by smoking-related ILD (25.9%), nonspecific interstitial pneumonia (18.6%), unclassifiable-ILD (14.8%), and others (7.4%).
Conclusion: This first single-center experience showed that TBLC using a flexible bronchoscopy and endobronchial balloon blocker with the fluoroscopic guidance under general anesthesia may be a safe and adequate diagnostic method for ILD patients in Korea. The diagnostic yield of MDD was 85.2%. Further studies are needed to evaluate the diagnostic yield and confidence of TBLC.
|
|
KEYWORD
|
|
Interstitial Lung Disease, Diagnosis, Transbronchial Lung Cryobiopsy, Multidisciplinary Discussion
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|